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Báo cáo y học: "Simultaneous transcription of duplicated var2csa gene copies in individual Plasmodium falciparum parasites"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Simultaneous transcription of duplicated var2csa gene copies in individual Plasmodium falciparum parasites. | Open Access Simultaneous transcription of duplicated var2csa gene copies in individual Plasmodium falciparum parasites Kim JM BrolinH Ulf RibackeH Sandra Nilsson Johan Ankarklev k Kirsten Moll Mats Wahlgren and Qijun Chen A Addresses Department of Microbiology Tumor and Cell Biology Nobels Vag 16 Karolinska Institutet SE-171 77 Stockholm Sweden. Swedish Institute for Infectious Disease Control Nobels Vag 18 SE-171 82 Stockholm Sweden. Department of Cell and Molecular Biology Uppsala University Husargatan 3 SE-751 21 Uppsala Sweden. Key Laboratory of Zoonosis Ministry of Education Jilin University Xi An Da Lu 5333 Changchun 130062 China. Laboratory of Parasitology Institute of Pathogen Biology Chinese Academy of Medical Sciences Dong Dan San Tiao 9 Beijing 100730 China. H These authors contributed equally to this work. Correspondence QijunChen. Email qijun.chen@smi.se Published 22 October 2009 Genome Biology 2009 10 R117 doi 10.1186 gb-2009-10-10-r117 The electronic version of this article is the complete one and can be found online at http genomebiology.com 2009 10 10 R117 Received 6 May 2009 Revised 22 August 2009 Accepted 22 October 2009 2009 Brolin et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Single nucleotide polymorphisms are common in duplicated genes causing functional preservation alteration or silencing. The Plasmodium falciparum genes var2csa and Pf332 are duplicated in the haploid genome of the HB3 parasite line. Whereas the molecular function of Pf332 remains to be elucidated VAR2CSA is known to be the main adhesin in placental parasite sequestration. Sequence variations introduced upon duplication of these genes provide discriminative possibilities to analyze allele-specific .