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báo cáo khoa học: "A statistical model for genotype determination at a major locus in a progeny test design"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: A statistical model for genotype determination at a major locus in a progeny test design | Génét. Sél. Evol. 1988 20 2 211-226 A statistical model for genotype determination at a major locus in a progeny test design J.M. ELSEN Jacqueline vu TIEN KHANG and Pascale LE ROY Institut National de la Recherche Agronomique Station d Amelioration Génétique des Animaux Centre de Recherches de Toulouse B.p. 27 31326 Castanet-Tolosan Cedex France Summary Considering a normally distributed quantitative trait whose genetic variation is controlled by both an autosomal major locus and a polygenic component and whose expression is influenced by environmental factors a mixed model was developed to classify sires and daughters for their genotypes at the major locus in a progeny test design. Repeatability and genetic parameters reflecting the polygenic variation were assumed to be known. Posterior distribution of the sire genotypes and that of the daughters given the sire genotypes were derived. A method was proposed to estimate these posterior probabilities as well as the unknown parameters and a method using the likelihood ratios to test specific genetic hypotheses was suggested. An iterative two-step procedure similar to the EM expectation-maximization algorithm was used to estimate the posterior probabilities and the unknown parameters. The operational value of this approach was tested with simulated data. Key words major locus progeny test genotypic classification maximum likelihood. Resume Un modèle statistique pour la determination du genotype à un locus majeur dans un test sur descendance S appliquant à un caractère quantitatif à distribution normale dont la variabilité génétique est contrôlée à la fois par un locus majeur autosomal et par une composante polygệnique et dont 1 expression est influencee par des facteurs de milieu un modèle mixte est développé afin de determiner le genotype au locus majeur des pères et de leurs filles dans un test sur descendance. La répétabilité et les paramètres génétiques relatifs à la composante polygénique sont supposes connus. La