Đang chuẩn bị liên kết để tải về tài liệu:
Báo cáo y học: "Genome sequence of the stramenopile Blastocystis, a human anaerobic parasite"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Genome sequence of the stramenopile Blastocystis, a human anaerobic parasite. | Denoeud et al. Genome Biology 2011 12 R29 http genomebiology.eom content 12 3 R29 Genome Biology RESEARCH Open Access Genome sequence of the stramenopile Blastocystis a human anaerobic parasite 1 2.3 1 2 3 s P s - 1 2 3 France Denoeud Michael Roussel Benjamin Noel Ivan Wawrzyniak Corinne Da Silva Marie Diogon Crl i I- r z t I I ỉ I4 5 6 7 I I D r r A I r r Ar m - v-xM8 9 A I A r I 11 r IIXZ1I D r I 11 I v 1 o zk -X t r z zx c zx zx I imnr 1 Eric Viscogliosi Céline Brochier-Armanet Arnaud Couloux Julie Poulain Béatrice Segurens 1 2.3 2.3 2.3 10 10 Véronique Anthouard1 Catherine Texier2 3 Nicolas Blot2 3 Philippe Poirier2 3 Geok Choo Ng10 Kevin SW Tan10 1 1 1 2.3 1 2.3 Frangois Artiguenave Olivier Jaillon Jean-Marc Aury Frédéric Delbac Patrick Wincker Christian P Vivarès and Hicham El Alaoui2 3 Abstract Background Blastocystis is a highly prevalent anaerobic eukaryotic parasite of humans and animals that is associated with various gastrointestinal and extraintestinal disorders. Epidemiological studies have identified different subtypes but no one subtype has been definitively correlated with disease. Results Here we report the 18.8 Mb genome sequence of a Blastocystis subtype 7 isolate which is the smallest stramenopile genome sequenced to date. The genome is highly compact and contains intriguing rearrangements. Comparisons with other available stramenopile genomes plant pathogenic oomycete and diatom genomes revealed effector proteins potentially involved in the adaptation to the intestinal environment which were likely acquired via horizontal gene transfer. Moreover Blastocystis living in anaerobic conditions harbors mitochondria-like organelles. An incomplete oxidative phosphorylation chain a partial Krebs cycle amino acid and fatty acid metabolisms and an iron-sulfur cluster assembly are all predicted to occur in these organelles. Predicted secretory proteins possess putative activities that may alter host physiology such as proteases protease-inhibitors .