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Báo cáo y học: " Predictors of disease progression in HIV infection: a review"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Predictors of disease progression in HIV infection: a review. | BioMed Central AIDS Research and Therapy Review Open Access Predictors of disease progression in HIV infection a review Simone E Langford 1 2 Jintanat Ananworanich2 and David A Cooper2 3 Address 1Monash University Melbourne Australia 2The HIV Netherlands Australia Thailand Research Collaboration Bangkok Thailand and 3The National Centre in HIV Epidemiology and Clinical Research Sydney Australia University of New South Wales Sydney Australia Email Simone E Langford - simone.langford@med.monash.edu.au Jintanat Ananworanich - jintanat.a@searchthailand.org David A Cooper - dcooper@nchecr.unsw.edu.au Corresponding author Published 14 May 2007 Received 6 November 2006 AIDS Research and Therapy 2007 4 11 doi l0.ll86 l742-6405-4-ll Accepted 14 May 2007 This article is available from http www.aidsrestherapy.cOm content 4 l l l 2007 Langford et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract During the extended clinically latent period associated with Human Immunodeficiency Virus HIV infection the virus itself is far from latent. This phase of infection generally comes to an end with the development of symptomatic illness. Understanding the factors affecting disease progression can aid treatment commencement and therapeutic monitoring decisions. An example of this is the clear utility of CD4 T-cell count and HIV-RNA for disease stage and progression assessment. Elements of the immune response such as the diversity of HIV-specific cytotoxic lymphocyte responses and cell-surface CD38 expression correlate significantly with the control of viral replication. However the relationship between soluble markers of immune activation and disease progression remains inconclusive. In patients on treatment sustained virological rebound