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Báo cáo y học: "Bone healing after median sternotomy: A comparison of two hemostatic device"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Bone healing after median sternotomy: A comparison of two hemostatic devices. | Vestergaard et al. Journal of Cardiothoracic Surgery 2010 5 117 http www.cardiothoracicsurgery.Org content 5 1 117 JOTS JOURNAL OF CARDIOTHORACIC SURGERY RESEARCH ARTICLE Open Access Bone healing after median sternotomy A comparison of two hemostatic devices Rikke F Vestergaard1 2 Henrik Jensen1 2 Stefan Vind-Kezunovic1 2 Thomas Jakobsen3 Kjeld Soballe3 John M Hasenkam1 2 Abstract Background Bone wax is traditionally used as part of surgical procedures to prevent bleeding from exposed spongy bone. It is an effective hemostatic device which creates a physical barrier. Unfortunately it interferes with subsequent bone healing and increases the risk of infection in experimental studies. Recently a water-soluble synthetic hemostatic compound Ostene was introduced to serve the same purpose as bone wax without hampering bone healing. This study aims to compare sternal healing after application of either bone wax or Ostene . Methods Twenty-four pigs were randomized into one of three treatment groups Ostene bone wax or no hemostatic treatment control . Each animal was subjected to midline sternotomy. Either Ostene or bone wax was applied to the spongy bone surfaces until local hemostasis was ensured. The control group received no hemostatic treatment. The wound was left open for 60 min before closing to simulate conditions alike those of cardiac surgery. All sterni were harvested 6 weeks after intervention. Bone density and the area of the bone defect were determined with peripheral quantitative CT-scanning bone healing was displayed with plain X-ray and chronic inflammation was histologically assessed. Results Both CT-scanning and plain X-ray disclosed that bone healing was significantly impaired in the bone wax group p 0.01 compared with the other two groups and the former group had significantly more chronic inflammation p 0.01 than the two latter. Conclusion Bone wax inhibits bone healing and induces chronic inflammation in a porcine model. Ostene treated animals .