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Báo cáo y học: "Effect of pentoxifylline on preventing acute kidney injury after cardiac surgery by measuring urinary neutrophil gelatinase - associated lipocalin"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: Effect of pentoxifylline on preventing acute kidney injury after cardiac surgery by measuring urinary neutrophil gelatinase - associated lipocalin. | Barkhordari et al. Journal of Cardiothoracic Surgery 2011 6 8 http www.cardiothoracicsurgery.Org content 6 1 8 JCTS JOURNAL OF CARDIOTHORACIC SURGERY RESEARCH ARTICLE Open Access Effect of pentoxifylline on preventing acute kidney injury after cardiac surgery by measuring urinary neutrophil gelatinase - associated lipocalin 1 23 1 4 Khosro Barkhordari Abbasali Karimi Akbar Shafiee Hasan Soltaninia Mohammad Reza Khatami Kiomars Abbasi2 Fardin Yousefshahi1 Babak Haghighat1 Virginia Brown5 Abstract Background Based on Acute Kidney Injury Network AKIN criteria we considered acute kidney injury AKI as an absolute increase in the serum creatinine sCr level of more than or equal to 0.3 mg dl or 50 . The introduction of Urinary neutrophil gelatinase-associated lipocalin UNGAL has conferred earlier diagnosis of AKI. Pentoxifylline PTX a non-specific phosphodiesterase inhibitor can suppress the production of some factors of inflammatory response and presumably prevent AKI. We examined the PTX on the development of AKI in cardiac surgery patients by measuring the levels of UNGAL. Materials and methods We performed a double blind randomized clinical trial enrolling 28 consecutive patients undergoing elective coronary artery bypass graft CABG surgery. Patients were divided into two groups one to receive PTX 5 mg kg intravenous bolus injection followed by 1.5 mg kg h continuous intravenous infusion until 3 hours after cessation of CPB and the other group received placebo. UNGAL was measured before 3 and 24 hours after surgery. In addition serum creatinine was measured before and 24 48 72 and 96 hours after surgery and C-reactive protein CRP only 24 hours postoperatively. Results Both groups did not differ in demographic and baseline characteristics. 12 patients developed AKI 48 hours after surgery 5 of them were in the intervention group and 7 in the control group p 0.445 . There was an increase of UNGAL in both groups postoperatively although not significant. Mean sCr was .