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Báo cáo y học: " High prevalence of lung cancer in a surgical cohort of lung cancer patients a decade after smoking cessation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Wertheim cung cấp cho các bạn kiến thức về ngành y đề tài: High prevalence of lung cancer in a surgical cohort of lung cancer patients a decade after smoking cessation. | Mong et al. Journal of Cardiothoracic Surgery 2011 6 19 http www.cardiothoracicsurgery.Org content 6 1 19 JCTS JOURNAL OF CARDIOTHORACIC SURGERY RESEARCH ARTICLE Open Access High prevalence of lung cancer in a surgical cohort of lung cancer patients a decade after smoking cessation 1 12 2 3 4 2 Cindy Mong Edward B Garon Clark Fuller Ali Mahtabifard James Mirocha Zab Mosenifar Robert McKenna Abstract Background This study was designed to assess the prevalence of smoking at time of lung cancer diagnosis in a surgical patient cohort referred for cardiothoracic surgery. Methods Retrospective study of lung cancer patients n 626 referred to three cardiothoracic surgeons at a tertiary care medical center in Southern California from January 2006 to December 2008. Relationships among years of smoking cessation smoking status and tumor histology were analyzed with Chi-square tests. Results Seventy-seven percent 482 had a smoking history while 11.3 71 were current smokers. The length of smoking cessation to cancer diagnosis was 1 year for 56 13.6 1-10 years for 110 26.8 11-20 years for 87 21.2 21-30 years for 66 16.1 31-40 years for 44 10.7 41-50 years for 40 9.7 and 51-60 years for 8 1.9 . The mean cessation was 18.1 15.7 years n 411 former smokers . Fifty-nine percent had stage 1 disease and 68.0 had adenocarcinoma. Squamous cell carcinoma was more prevalent in smokers 15.6 vs. 8.3 p 0.028 adenocarcinoma was more prevalent in never-smokers 79.9 versus 64.3 p 0.0004 . The prevalence of adenocarcinoma varied inversely with pack year p 0.0001 and directly with years of smoking cessation p 0.0005 . Conclusions In a surgical lung cancer cohort the majority of patients were smoking abstinent greater than one decade before the diagnosis of lung cancer. Background Lung cancer is the leading cause of cancer death accounting for 29 of total cancer deaths in the US and over 1.4 million deaths worldwide. In the US alone lung cancer claimed the lives of 171 840 individuals in 2008 and .