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Báo cáo khoa hoc:" A study of association between common variation in the growth hormone-chorionic somatomammotropin hormone gene cluster and adult fasting insulin in a UK Caucasian population"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: A study of association between common variation in the growth hormone-chorionic somatomammotropin hormone gene cluster and adult fasting insulin in a UK Caucasian population | Journal of Negative Results in BioMedicine BioMed Central Open Access A study of association between common variation in the growth hormone-chorionic somatomammotropin hormone gene cluster and adult fasting insulin in a UK Caucasian population Rachel M Freathy Simon MS Mitchell Beatrice Knight Beverley Shields Michael N Weedon Andrew T Hattersley and Timothy M Frayling Address Institute of Biomedical and Clinical Science Peninsula Medical School Exeter UK Email Rachel M Freathy - rachel.freathy@pms.ac.uk Simon MS Mitchell - S.M.S.Mitchell@student.liverpool.ac.uk Beatrice Knight - B.A.Knight@ex.ac.uk Beverley Shields - B.Shields@ex.ac.uk Michael N Weedon - m.n.weedon@ex.ac.uk AndrewT Hattersley - andrew.hattersley@pms.ac.uk Timothy M Frayling - tim.frayling@pms.ac.uk Corresponding author Published 24 November 2006 Received 24 May 2006 J rm J. m I mz i riri r m Accepted 24 November 2006 Journal of Negative Results in BioMedicine 2006 5 18 doi l0.ll86 1477-5751-5-18 This article is available from http www.jnrbm.cOm content 5 1 18 2006 Freathy et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Reduced growth during infancy is associated with adult insulin resistance. In a UK Caucasian cohort the CSHI.0I microsatellite polymorphism in the growth hormone-chorionic somatomammotropin hormone gene cluster was recently associated with increases in adult fasting insulin of approximately 23 pmol l for TT homozygote males compared to D1D1 or D2D2 homozygotes P 0.001 and 0.009 n 206 and 92 respectively but not for females. TT males additionally had a 547-g lower weight at 1 year n 270 P 0.008 than D2D2 males. We sought to replicate these data in healthy UK Caucasian subjects. We genotyped 1396 subjects fathers .