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Báo cáo khoa hoc:" Effects of bone marrow cell transplant on thyroid function in an I131-induced low T4 and elevated TSH rat model"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Effects of bone marrow cell transplant on thyroid function in an I131-induced low T4 and elevated TSH rat model | BioMed Central Journal of Negative Results in BioMedicine Research Open Access Effects of bone marrow cell transplant on thyroid function in an Il3l-induced low T4 and elevated TSH rat model Gustavo E Guajardo-Salinas Juan A Carvajal Ángel A Gaytan-Ramos Luis Arroyo Alberto G López-Reyes José F Islas Beiman G Cano Netzahualcoyótl Arroyo-Currás Alfredo Dávalos Gloria Madrid and Jorge E Moreno-Cuevas Address Cell Therapy Laboratory ITESM School of Medicine 3000 Ave. Morones Prieto Monterrey NL 64710 México Email Gustavo E Guajardo-Salinas - guegsa@itesm.mx Juan A Carvajal - A00644163@itesm.mx Ángel A Gaytan-Ramos - A00791068@itesm.mx Luis Arroyo - A00791784@itesm.mx Alberto G Lopez-Reyes - allorey@itesm.mx José F Islas - chepo3d@itesm.mx Beiman G Cano - A00790999@itesm.mx Netzahualcoyótl Arroyo-Currás - A00790778@itesm.mx Alfredo Dávalos - A00915358@itesm.mx Gloria Madrid - gloria.madrid@gmail.com Jorge E Moreno-Cuevas - jemoreno@itesm.mx Corresponding author Published 18 January 2007 Received 08 May 2006 J. . n riri I Accepted 18 January 2007 Journal of Negative Results in BioMedicine 2007 6 1 doi l0.ll86 l 477-5751-6-1 This article is available from http www.jnrbm.cOm content 6 1 1 2007 Guajardo-Salinas et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background We developed a study using low dose radioactive iodine creating an animal model of transient elevation of thyroid stimulating hormone TSH . Male derived bone marrow cells were transplanted to asses their effect on thyroid function and their capability to repair the thyroid parenchyma. Results At 40 an 80 days after I131 treatment the study groups TSH and T4 serum values both increased and decreased significantly respectively compared to the negative .