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Báo cáo y học: " Alterations in transcriptional responses associated with vascular aging"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Alterations in transcriptional responses associated with vascular aging. | Journal of Inflammation BioMed Central Open Access Review Alterations in transcriptional responses associated with vascular aging Yumei Zhan Lei Yuan and Peter Oettgen Address Division of Cardiology and Molecular and Vascular Biology Department of Medicine Center for Vascular Biology Research Beth Israel Deaconess Medical Center Boston Massachusetts USA Email Yumei Zhan - yzhan@caregroup.harvard.edu Lei Yuan - lyuan1@bidmc.harvard.edu Peter Oettgen - joettgen@bidmc.harvard.edu Corresponding author Published 21 May 2009 Received 5 March 2009 Journal of Inflammation 2009 6 16 doi l0.ll86 l476-9255-6-l6 Accepted 2l May 2009 This article is available from http www.journal-inflammation.cOm content 6 l l6 2009 Zhan et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Vascular aging is an independent risk factor for cardiovascular disease that can occur in the absence of other traditional risk factors. Inflammation is a hallmark of vascular aging that ultimately leads to structural changes in the vessel wall including an increase in medial thickness and perivascular fibrosis. Several classes of transcription factors have been identified that participate in the regulation of cellular responses associated with vascular aging. Nuclear factor NF -kB is the prototypic example of a transcriptional activator in the setting of inflammation being activated in response to multiple inflammatory mediators including pro-inflammatory cytokines and bacterial endotoxin. In contrast the activation of the nuclear hormone receptor and transcription factor peroxisome proliferator-activated receptor-alpha PPAR-a results in its translocation from the cell surface to the nucleus where it exerts anti-inflammatory effects. Vascular aging is also