Đang chuẩn bị liên kết để tải về tài liệu:
Báo cáo y học: "Database analysis of children and adolescents with Bipolar Disorder consuming a micronutrient formula"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Database analysis of children and adolescents with Bipolar Disorder consuming a micronutrient formula | Rucklidge et al. BMC Psychiatry 2010 10 74 http www.biomedcentral.com 1471-244X 10 74 BMC Psychiatry RESEARCH ARTICLE Open Access Database analysis of children and adolescents with Bipolar Disorder consuming a micronutrient formula Julia J Rucklidge1 Dermot Gately2t Bonnie J Kaplan3t Abstract Background Eleven previous reports have shown potential benefit of a 36-ingredient micronutrient formula known as EMPowerplus for the treatment of psychiatric symptoms. The current study asked whether children 7-18 years with pediatric bipolar disorder PBD benefited from this same micronutrient formula the impact of Attention-Deficit Hyperactivity Disorder ADHD on their response was also evaluated. Methods Data were available from an existing database for 120 children whose parents reported a diagnosis of PBD 79 were taking psychiatric medications that are used to treat mood disorders 24 were also reported as ADHD. Using Last Observation Carried Forward LOCF data were analyzed from 3 to 6 months of micronutrient use. Results At LOCF mean symptom severity of bipolar symptoms was 46 lower than baseline effect size ES 0.78 p 0.001 . In terms of responder status 46 experienced 50 improvement at LOCF with 38 still taking psychiatric medication 52 drop from baseline but at much lower levels 74 reduction in number of medications being used from baseline . The results were similar for those with both ADHD and PBD a 43 decline in PBD symptoms ES 0.72 and 40 in ADHD symptoms ES 0.62 . An alternative sample of children with just ADHD symptoms n 41 showed a 47 reduction in symptoms from baseline to LOCF ES 1.04 . The duration of reductions in symptom severity suggests that benefits were not attributable to placebo expectancy effects. Similar findings were found for younger and older children and for both sexes. Conclusions The data are limited by the open label nature of the study the lack of a control group and the inherent self-selection bias. While these data cannot establish efficacy