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Báo cáo y học: "Clinical importance and impact on the households of oseltamivir-resistant seasonal A/H1N1 influenza virus in healthy children in Italy"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Clinical importance and impact on the households of oseltamivir-resistant seasonal A/H1N1 influenza virus in healthy children in Italy | Esposito et al. Virology Journal 2010 7 202 http www.virologyj.eom content 7 1 202 VIROLOGY JOURNAL SHORT REPORT Open Access Clinical importance and impact on the households of oseltamivir-resistant seasonal A H1N1 influenza virus in healthy children in Italy 1 11112 Susanna Esposito Claudio Giuseppe Molteni Cristina Daleno Antonia Valzano Emilio Fossali Liviana Da Dalt S I i r i s 13 c I I z V I s D ri I 7 7r r Z X4 D I I rd I s r r h I z 5 r I í I s z t I I I 4- - .2 r I z h f- rd I r 6 A r ị I I ì lz M L 7 Valerio Cecinati Eugenia Bruzzese Raffaella Giacchino Carlo Giaquinto Carlotta Galeone Angie Lackenby Nicola Principi1 Abstract A resistance of A H1N1 influenza viruses to oseltamivir has recently emerged in a number of countries. However the clinical and socioeconomic importance of this resistance has not been precisely defined. As children have the highest incidence of influenza infection and are at high risk of severe disease the aim of this study was to evaluate the clinical importance and the impact on the households of oseltamivir-resistant seasonal A H1N1 influenza virus in an otherwise healthy pediatric population. A total of 4 726 healthy children younger than 15 years with influenza-like illness were tested for influenza viruses by real-time polymerase chain reaction in the winters of 20072008 and 2008-2009 in Italy. The influenza A virus-positive samples underwent neuraminidase gene analysis using pyrosequencing to identify mutations H275Y and N294 S in A H1N1 and E119V R292K and N294 S in A H3N2. Among the A H1N1 subtypes the H275Y mutation was found in 2 126 samples taken in 2007-2008 1.6 and in all 17 samples 100 p 0.0001 taken in 2008-2009. No other mutation was identified in any of the A H1N1 or A H3N2 influenza viruses. No significant differences were found in terms of clinical importance or impact on the households between the children with oseltamivir-resistant seasonal A H1N1 influenza virus and those with the wild-type. The spread of .