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Báo cáo y học: "Hepatitis C virus core, NS3, NS4B and NS5A are the major immunogenic proteins in humoral immunity in chronic HCV infection"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Hepatitis C virus core, NS3, NS4B and NS5A are the major immunogenic proteins in humoral immunity in chronic HCV infection | Virology Journal BioMed Central Research Hepatitis C virus core NS3 NS4B and NS5A are the major immunogenic proteins in humoral immunity in chronic HCV infection Maarit Sillanpăă 1 Krister Melén1 Păivi Porkka1 Riku Fagerlund1 Kaisu Nevalainen1 Maija Lappalainen2 and Ilkka Julkunen1 Open Access Address Department of Vaccination and Immune Protection National Institute for Health and Welfare THL P.O. Box 30 FI-00271 Helsinki Finland and 2Department of Virology Laboratory Services HUSLAB Helsinki University Hospital FI-00014 Helsinki Finland Email Maarit Sillanpăă - maarit.sillanpaa@thl.fi Krister Melén - krister.melen@thl.fi Păivi Porkka - paivi.porkka@helsinki.fi Riku Fagerlund - riku.fagerlund@thl.fi Kaisu Nevalainen - kaisu.nevalainen@gmail.com Maija Lappalainen - maija.lappalainen@hus.fi Ilkka Julkunen - ilkka.julkunen@thl.fi Corresponding author Published 23 June 2009 Received 30 April 2009 Virology Journal 2009 6 84 doi 10.1186 1743-422X-6-84 Accepted 23 June 2009 This article is available from http www.virologyj.eom content 6 1 84 2009 Sillanpaa et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background The viral genome of hepatitis C virus constitutes a 9.6-kb single-stranded positivesense RNA which encodes altogether II viral proteins. In order to study the humoral immune responses against different HCV proteins in patients suffering from chronic HCV infection we produced three structural core EI and E2 and six nonstructural proteins NS2 NS3 NS4A NS4B NS5A and NS5B in Sf9 insect cells by using the baculovirus expression system. Results The recombinant HCV core EI E2 NS2 NS3 NS4A NS4B NS5A and NS5B proteins were purified .