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Báo cáo khoa học: "Conserved positive selection signals in gp41 across multiple subtypes and difference in selection signals detectable in gp41 sequences sampled during acute and chronic HIV-1 subtype C infection"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành y học dành cho các bạn tham khảo đề tài: Conserved positive selection signals in gp41 across multiple subtypes and difference in selection signals detectable in gp41 sequences sampled during acute and chronic HIV-1 subtype C infection | Virology Journal BioMed Central Research Conserved positive selection signals in gp41 across multiple subtypes and difference in selection signals detectable in gp41 sequences sampled during acute and chronic HIV-1 subtype C infection Gama P Bandawe 1 Darren P Martin1 Florette Treurnicht1 Koleka Mlisana2 Salim S Abdool Karim2 Carolyn Williamson1 and The CAPRISA 002 Acute Infection Study Team2 Open Access Address institute of Infectious Disease and Molecular Medicine Faculty of Health Sciences University of Cape Town Anzio Road Observatory 7925 South Africa and 2Doris Duke Medical Research Institute Nelson R Mandela School of Medicine University of KwaZulu-Natal Private Bag X7 Congella 4013 South Africa Email Gama P Bandawe - gama.bandawe@uct.ac.za Darren P Martin - darrin.martin@uct.ac.za Florette Treurnicht - florette.treurnicht@uct.ac.za Koleka Mlisana - mlisanak@ukzn.ac.za Salim S Abdool Karim - karims1@ukzn.ac.za Carolyn Williamson - carolyn.williamson@uct.ac.za The CAPRISA 002 Acute Infection Study Team - caprisa@ukzn.ac.za Corresponding author Published 24 November 2008 Received 29 September 2008 Accepted 24 November 2008 Virology journal 2008 5 141 doi 10.1186 1743-422X-5-141 This article is available from http www.virologyj.com content 5 1 141 2008 Bandawe et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Background The high diversity of HIV variants driving the global AIDS epidemic has caused many to doubt whether an effective vaccine against the virus is possible. However by identifying the selective forces that are driving the ongoing diversification of HIV and characterising their genetic consequences it may be .