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Báo cáo hóa học: " The effect of acyclovir on the tubular secretion of creatinine in vitro"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: The effect of acyclovir on the tubular secretion of creatinine in vitro | Gunness et al. Journal of Translational Medicine 2010 8 139 http www.translational-medicine.eom content 8 1 139 TRANSLATIONAL MEDICINE RESEARCH Open Access The effect of acyclovir on the tubular secretion of creatinine in vitro Patrina Gunness1 2 Katarina Aleksa 1 Gideon Koren1 2 Abstract Background While generally well tolerated severe nephrotoxicity has been observed in some children receiving acyclovir. A pronounced elevation in plasma creatinine in the absence of other clinical manifestations of overt nephrotoxicity has been frequently documented. Several drugs have been shown to increase plasma creatinine by inhibiting its renal tubular secretion rather than by decreasing glomerular filtration rate GFR . Creatinine and acyclovir may be transported by similar tubular transport mechanisms thus it is plausible that in some cases the observed increase in plasma creatinine may be partially due to inhibition of tubular secretion of creatinine and not solely due to decreased GFR. Our objective was to determine whether acyclovir inhibits the tubular secretion of creatinine. Methods Porcine LLC-PK1 and human HK-2 renal proximal tubular cell monolayers cultured on microporous membrane filters were exposed to 2-14C creatinine 5 pM in the absence or presence of quinidine 1E 03 pM cimetidine 1E 03 pM or acyclovir 22 - 89 pM in incubation medium. Results Results illustrated that in evident contrast to quinidine acyclovir did not inhibit creatinine transport in LLC-PK1 and HK-2 cell monolayers. Conclusions The results suggest that acyclovir does not affect the renal tubular handling of creatinine and hence the pronounced transient increase in plasma creatinine is due to decreased GFR and not to a spurious increase in plasma creatinine. Background Acyclovir is an antiviral agent that is commonly used to treat severe viral infections including herpes simplex and varicella zoster in children 1 . Acyclovir is generally well tolerated 2 however in some cases severe nephrotoxicity