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báo cáo hóa học: " The effect of pharmacological treatment on gait biomechanics in peripheral arterial disease patients"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: The effect of pharmacological treatment on gait biomechanics in peripheral arterial disease patients | Huisinga et al. Journal of NeuroEngineering and Rehabilitation 2010 7 25 http www.jneuroengrehab.eom content 7 1 25 J NER JOURNAL OF NEUROENGINEERING AND REHABILITATION RESEARCH Open Access The effect of pharmacological treatment on gait biomechanics in peripheral arterial disease patients Jessie M Huisinga 1 Iraklis I Pipinos2 Jason M Johanning2 and Nicholas Stergiou 1 3 Abstract Background Pharmacological treatment has been advocated as a first line therapy for Peripheral Arterial Disease PAD patients suffering from intermittent claudication. Previous studies document the ability of pharmacological treatment to increase walking distances. However the effect of pharmacological treatment on gait biomechanics in PAD patients has not been objectively evaluated as is common with other gait abnormalities. Methods Sixteen patients were prescribed an FDA approved drug Pentoxifylline or Cilostazol for the treatment of symptomatic PAD. Patients underwent baseline gait testing prior to medication use which consisted of acquisition of ground reaction forces and kinematics while walking in a pain free state. After three months of treatment patients underwent repeat gait testing. Results Patients with symptomatic PAD had significant gait abnormalities at baseline during pain free walking as compared to healthy controls. However pharmacological treatment did not produce any identifiable alterations on the biomechanics of gait of the PAD patients as revealed by the statistical comparisons performed between pre and posttreatment and between post-treatment and the healthy controls. Conclusions Pharmacological treatment did not result in statistically significant improvements in the gait biomechanics of patients with symptomatic PAD. Future studies will need to further explore different cohorts of patients that have shown to improve significantly their claudication distances and or their muscle fiber morphology with the use of pharmacological treatment and determine if this is .