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báo cáo hóa học:" Effect of borax on immune cell proliferation and sister chromatid exchange in human chromosomes Malinee Pongsavee"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Effect of borax on immune cell proliferation and sister chromatid exchange in human chromosomes Malinee Pongsavee | Journal of Occupational Medicine and Toxicology BioMed Zentral Research Effect of borax on immune cell proliferation and sister chromatid exchange in human chromosomes Malinee Pongsavee Address Department of Medical Technology Faculty of Allied Health Sciences Thammasat University Rangsit Campus Patumthani 12121 Thailand E-mail malineep@tu.ac.th Open Access Published 30 October 2009 Received 16 April 2009 Journal of Occupational Medicine and Toxicology 2009 4 27 doi 10.1 186 1745-6673-4-27 Accepted 30 October 2009 This article is available from http www.occup-med.Com content 4 1 27 2009 Pongsavee licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Borax is used as a food additive. It becomes toxic when accumulated in the body. It causes vomiting fatigue and renal failure. Methods The heparinized blood samples from 40 healthy men were studied for the impact of borax toxicity on immune cell proliferation lymphocyte proliferation and sister chromatid exchange in human chromosomes. The MTT assay and Sister Chromatid Exchange SCE technic were used in this experiment with the borax concentrations of 0.1 0.15 0.2 0.3 and 0.6 mg ml. Results It showed that the immune cell proliferation lymphocyte proliferation was decreased when the concentrations of borax increased. The borax concentration of 0.6 mg ml had the most effectiveness to the lymphocyte proliferation and had the highest cytotoxicity index CI . The borax concentrations of 0.15 0.2 0.3 and 0.6 mg ml significantly induced sister chromatid exchange in human chromosomes P 0.05 . Conclusion Borax had effects on immune cell proliferation lymphocyte proliferation and induced sister chromatid exchange in human chromosomes. Toxicity of borax may lead to cellular .