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báo cáo hóa học:" Effect of combined treatment with alendronate and calcitriol on femoral neck strength in osteopenic rats"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học quốc tế đề tài : Effect of combined treatment with alendronate and calcitriol on femoral neck strength in osteopenic rats | Journal of Orthopaedic Surgery and Research BioMed Central Open Access Research article Effect of combined treatment with alendronate and calcitriol on femoral neck strength in osteopenic rats Yoshinari Nakamura 1 Masatoshi Naito1 Kazuo Hayashi2 Abbas Fotovati2 and Samah Abu-Ali2 Address Department of Orthopaedic Surgery Fukuoka University School of Medicine Fukuoka Japan and 2Rheumatology and Arthritis Center Fukuoka Wajiro Hospital 2-2-75 Wajirooka Higashi-ku Fukuoka Japan Email Yoshinari Nakamura - y.nakamura725@moon.email.ne.jp Masatoshi Naito - naito@fukuoka-u.ac.jp Kazuo Hayashi - khayashi2578jp@yahoo.co.jp Abbas Fotovati - fotovatiabbas157@yahoo.co.jp Samah Abu-Ali - samahabustar@yahoo.co.jp Corresponding author Published 17 December 2008 Received 10 February 2008 Journal of Orthopaedic Surgery and Research 2008 3 51 doi l0.ll86 l749-799X-3-5 I Accepted I7 December 2008 This article is available from http www.josr-online.cOm content 3 1 51 2008 Nakamura et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Hip fracture is associated with pronounced morbidity and excess mortality in elderly women with postmenopausal osteoporosis. Many drugs have been developed to treat osteoporosis and to reduce the risk of osteoporotic fractures. We investigated the effects of combined alendronate and vitamin D3 treatment on bone mass and fracture load at the femoral neck in ovariectomized OVX rats and evaluated the relationship between bone mass parameters and femoral neck strength. Methods Thirty 12-week-old female rats underwent either a sham-operation n 6 or OVX n 24 . Twenty weeks later OVX rats were further divided into four groups and received daily doses of either saline alone 0.1 mg kg alendronate 0.1 pg