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Báo cáo hóa học: " Evidence that the Nijmegen breakage syndrome protein, an early sensor of double-strand DNA breaks (DSB), is involved in HIV-1 post-integration repair by recruiting the ataxia telangiectasia-mutated kinase in a "

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Evidence that the Nijmegen breakage syndrome protein, an early sensor of double-strand DNA breaks (DSB), is involved in HIV-1 post-integration repair by recruiting the ataxia telangiectasia-mutated kinase in a | Virology Journal BioMed Central Research Evidence that the Nijmegen breakage syndrome protein an early sensor of double-strand DNA breaks DSB is involved in HIV-1 post-integration repair by recruiting the ataxia telangiectasia-mutated kinase in a process similar to but distinct from cellular DSB repair Johanna A Smith1 5 Feng-Xiang Wang1 5 Hui Zhang1 5 Kou-Juey Wu2 5 Kevin Jon Williams1 3 5 and René Daniel 1 4 5 Open Access Address division of Infectious Diseases - Center for Human Virology Kimmel Cancer Center Thomas Jefferson University Philadelphia PA USA institute of Biochemistry and Molecular Biology National Yang-Ming University Taipei Taiwan 3Division of Endocrinology Thomas Jefferson University Philadelphia USA 4Kimmel Cancer Center Immunology Program Thomas Jefferson University Philadelphia PA USA and 5704G Abramson Research Center 3615 Civic Center Boulevard Philadelphia PA 19104 USA Email Johanna A Smith - Johanna.Smith@jefferson.edu Feng-Xiang Wang - wangf@email.chop.edu Hui Zhang - Hui.Zhang@jefferson.edu Kou-Juey Wu - kjwu2@ym.edu.tw Kevin Jon Williams - K_Williams@mail.jci.tju.edu René Daniel - Rene.Daniel@jefferson.edu Corresponding author Published 22 January 2008 Received 16 November 2007 Accepted 22 January 2008 Virology Journal 2008 5 11 doi l0.ll86 l 743-422X-5- II This article is available from http www.virologyj.cOm content 5 1 1 1 2008 Smith et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract__ Retroviral transduction involves integrase-dependent linkage of viral and host DNA that leaves an intermediate that requires post-integration repair PIR . We and others proposed that PIR hijacks the host cell double-strand