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Báo cáo hóa học: " Analysis of the nucleotide sequence of the guinea pig cytomegalovirus (GPCMV) genome"

Tuyển tập báo cáo các nghiên cứu khoa học quốc tế ngành hóa học dành cho các bạn yêu hóa học tham khảo đề tài: Analysis of the nucleotide sequence of the guinea pig cytomegalovirus (GPCMV) genome | Virology Journal BioMed Central Open Access Short report Analysis of the nucleotide sequence of the guinea pig cytomegalovirus GPCMV genome Mark R Schleiss 1 Alistair McGregor1 K Yeon Choi1 Shailesh V Date2 Xiaohong Cui3 and Michael A McVoy3 Address 1Center for Infectious Diseases and Microbiology Translational Research University of Minnesota 2001 6th Street SE Minneapolis MN 55455 USA 2Genentech Inc. 1 DNA Way South San Francisco CA 94080 USA and 3Division of Infectious Diseases Department of Pediatrics Virginia Commonwealth University School of Medicine P.O. Box 163 MCV Station Richmond VA 23298 USA Email Mark R Schleiss - schleiss@umn.edu Alistair McGregor - mcgre077@umn.edu K Yeon Choi - choix207@umn.edu Shailesh V Date - date.shailesh@gene.com Xiaohong Cui - xcui@vcu.edu Michael A McVoy - mmcvoy@vcu.edu Corresponding author Published 12 November 2008 Received 15 October 2008 Accepted 12 November 2008 Virology Journal 2008 5 139 doi l0.ll86 l743-422X-5-l39 This article is available from http www.virologyj.com content 5 l l39 2008 Schleiss et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract In this report we describe the genomic sequence of guinea pig cytomegalovirus GPCMV assembled from a tissue culture-derived bacterial artificial chromosome clone plasmid clones of viral restriction fragments and direct PCR sequencing of viral DNA. The GPCMV genome is 232 678 bp excluding the terminal repeats and has a GC content of 55 . A total of 105 open reading frames ORFs of 100 amino acids with sequence and or positional homology to other CMV ORFs were annotated. Positional and sequence homologs of human cytomegalovirus open reading frames UL23 through ULI22 were identified. Homology with other cytomegaloviruses was .