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báo cáo hóa học:" Analysis of machine perfusion benefits in kidney grafts: a preclinical study"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Analysis of machine perfusion benefits in kidney grafts: a preclinical study | Vaziri et al. Journal of Translational Medicine 2011 9 15 http www.translational-medicine.eom content 9 1 15 TRANSLATIONAL MEDICINE RESEARCH Open Access Analysis of machine perfusion benefits in kidney grafts a preclinical study MsỉHor 2 71ri1 2 D2201 THi lillior1 3 7 ProHorif Pi p2 ro2i I1 3 7 j lir Hol Pl irtana1 4 7 Por io K iilin1 MÍ I2C D f l22 f 2i irot 1 4 7 Nddei Vdziii ndpiidcl Iiiuilliei riedeiic D rdviedu Micnel Eugene Seige Milin Nicolds P CUdLduiei Thierry Hduet1 3 4 7 Benoit Bdrrou1 4 s 6 7 Abstract Background Mdchine perfusion MP hds potentidl benefits foi mdigindl oigdns such ds from decedsed from cdididc dedth donois DCD . Howevei there is still no consensus on MP benefits. We dimed to deteimine mdchine perfusion benefits on kidney grafts. Methods We evdludted kidney grafts pieseived in VidspdnUW oi KPS solutions eithei by CS oi MP in d DCD pig model 60 min wdim ischemid 24 h hypotheimic pieseivdtion . Endpoints weie function iecoveiy qudlity of function duiing follow up 3 month infldmmdtion fibrosis dnimdl suivivdl. Results VidspdnUW-CS dnimdls did not iecovei function while in othei gioups edily follow up showed simildi vdlues foi kidney function. Aldnine peptiddse dnd p-NAG dctivities in the uiine weie highei in CS thdn in MP gioups. Oxyddtive stress wds lowei in KPS-MP dnimdls. Histology wds improved by MP ovei CS. Suivivdl wds 0 in VidspdnUW-CS dnd 60 in othei gioups. Chionic infldmmdtion epithelidl-to-mesenchymdl transition dnd fibrosis weie lowest in KPS-MP followed by KPS-CS dnd VidspdnUW-MP. Conclusions With VidspdnUW effects of MP die obvious ds only MP kidney recovered function dnd dllowed suivivdl. With KPS the benefits of MP ovei CS die not directly obvious in the edily follow up peiiod dnd only histologicdl dndlysis uiindiy tubuldi enzymes dnd ied ox stdtus wds disciimindting. Chionic follow-up wds moie conclusive with d cledi superiority of MP ovei CS independently of the solution used. KPS wds proven supeiioi to VidspdnUW in edch .