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báo cáo hóa học:" Effect of multiple micronutrient supplementation on survival of HIV-infected children in Uganda: a randomized, controlled trial"

Tuyển tập các báo cáo nghiên cứu về hóa học được đăng trên tạp chí sinh học đề tài : Effect of multiple micronutrient supplementation on survival of HIV-infected children in Uganda: a randomized, controlled trial | Ndeezi et al. Journal of the International AIDS Society 2010 13 18 http www.jiasociety.Org content 13 1 18 RESEARCH JOURNALOF THE INTERNATIONAL AIDS SOCIETY Open Access Effect of multiple micronutrient supplementation on survival of HIV-infected children in Uganda a randomized controlled trial Grace Ndeezi 1 2 Thorkild Tylleskăr2 Christopher M Ndugwa1 and James KTumwine1 Abstract Background Micronutrient deficiencies compromise the survival of HIV-infected children in low-income countries. We assessed the effect of multiple micronutrient supplementation on the mortality of HIV-infected children in Uganda. Methods In a randomized controlled trial 847 children aged one to five years and attending HIV clinics in Uganda were stratified by antiretroviral therapy ART n 85 versus no ART n 762 . The children were randomized to six months of either twice the recommended dietary allowance of 14 micronutrients as the intervention arm vitamins A B1 B2 niacin B6 B12 C D and E folate zinc copper iodine and selenium or the standard recommended dietary allowance of six multivitamins vitamins A D2 B1 B2 C and niacin as a comparative standard-of-care arm. Mortality was analyzed at 12 months of follow up using Kaplan Meier curves and the log rank test. Results Mortality at 12 months was 25 out of 426 5.9 children in the intervention arm and 28 out of 421 6.7 in the comparative arms risk ratio 0.9 95 CI 0.5 - 1.5 . Two out of 85 2.4 children in the ART stratum died compared with 51 out of 762 6.7 in the non-ART stratum. Of those who died in the non-ART stratum 25 of 383 6.5 were in the intervention arm and 26 of 379 6.9 in the comparative arm risk ratio 1.0 95 CI 0.6 - 1.6 . There was no significant difference in survival at 12 months p 0.64 log rank test . In addition there was no significant difference in mean weight-for-height at 12 months 0.70 1.43 95 CI 0.52 - 0.88 for the intervention versus 0.59 1.15 95 CI 0.45 - 0.75 in the comparative arm. The mean CD4 cell count 1024 592 95