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Advances in Biochemical Engineering/Biotechnology

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Since the introduction of recombinant human growth hormone and insulin a quarter century ago, protein therapeutics has greatly broadened the horizon of health care. Many patients suffering with life-threatening diseases or chronic dysfunctions,whichweremedically untreatable not long ago, can attest to the wonder these drugs have achieved. Although the first generation of protein therapeutics was produced in recombinant Escherichia coli, most recent products usemammalian cells as production hosts.Not long after the first production of recombinant proteins in E. coli, itwas realized that the complex tasks of most post-translational modifications on proteins could only be efficiently carried out in mammalian cells. In the 1990s, we witnessed a rapid expansion of mammalian-cell-derived protein.

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