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Phase I clinical study of oral olaparib in pediatric patients with refractory solid tumors: Study protocol

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There is no established standard chemotherapy for recurrent pediatric solid tumors such as neuroblastoma and sarcoma. Since some of these tumor cells show dysfunctions in homologous recombination repair, the goal is to conduct a phase I study of olaparib, a poly(ADP-ribose) polymerase inhibitor. | Phase I clinical study of oral olaparib in pediatric patients with refractory solid tumors: Study protocol

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Phase I clinical study of oral olaparib in pediatric patients with refractory solid tumors: Study protocol

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