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Chapter 105. Malignancies of Lymphoid Cells (Part 1)

Harrison's Internal Medicine Chapter 105. Malignancies of Lymphoid Cells Malignancies of Lymphoid Cells: Introduction Malignancies of lymphoid cells range from the most indolent to the most aggressive human malignancies. These cancers arise from cells of the immune system at different stages of differentiation, resulting in a wide range of morphologic, immunologic, and clinical findings. Insights on the normal immune system have allowed a better understanding of these sometimes confusing disorders. Some malignancies of lymphoid cells almost always present as leukemia (i.e., primary involvement of bone marrow and blood), while others almost always present as lymphomas (i.e., solid tumors of the immune system). However,. | Chapter 105. Malignancies of Lymphoid Cells Part 1 Harrison s Internal Medicine Chapter 105. Malignancies of Lymphoid Cells Malignancies of Lymphoid Cells Introduction Malignancies of lymphoid cells range from the most indolent to the most aggressive human malignancies. These cancers arise from cells of the immune system at different stages of differentiation resulting in a wide range of morphologic immunologic and clinical findings. Insights on the normal immune system have allowed a better understanding of these sometimes confusing disorders. Some malignancies of lymphoid cells almost always present as leukemia i.e. primary involvement of bone marrow and blood while others almost always present as lymphomas i.e. solid tumors of the immune system . However other malignancies of lymphoid cells can present as either leukemia or lymphoma. In addition the clinical pattern can change over the course of the illness. This change is more often seen in a patient who seems to have a lymphoma and then develops the manifestations of leukemia over the course of the illness. Biology of Lymphoid Malignancies Concepts of the WHO Classification of Lymphoid Malignancies The classification of lymphoid cancers evolved steadily throughout the twentieth century. The distinction between leukemia and lymphoma was made early and separate classification systems were developed for each. Leukemias were first divided into acute and chronic subtypes based on average survival. Chronic leukemias were easily subdivided into those of lymphoid or myeloid origin based on morphologic characteristics. However a spectrum of diseases that were formerly all called chronic lymphoid leukemia has become apparent Table 105-1 . The acute leukemias were usually malignancies of blast cells with few identifying characteristics. When cytochemical stains became available it was possible to divide these objectively into myeloid malignancies and acute leukemias of lymphoid cells. Acute leukemias of lymphoid cells .