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Báo cáo sinh học: "The functional landscape of mouse gene expression"

Tuyển tập các báo cáo nghiên cứu về sinh học được đăng trên tạp chí sinh học Journal of Biology đề tài: The functional landscape of mouse gene expression. | J. Biol. Journal of Biology BioMed Central Research article Open Access The functional landscape of mouse gene expression Wen Zhang a Quaid D Morris Richard Chang Ofer Shai Malina A Bakowski Nicholas Mitsakakis Naveed Mohammad Mark D Robinson Ralph Zirngibl Eszter Somogyi Nancy Laurin Eftekhar Eftekharpour Eric Sat1 Jorg Grigull Qun Pan Wen-Tao Peng Nevan Krogan Jack Greenblatt Michael Fehlings Derek van der Kooy Jane Aubin Benoit G Bruneau Janet RossanC Benjamin J Blencowe Brendan J Frey and Timothy R Hughes Addresses Banting and Best Department of Medical Research Department of Medical Genetics and Microbiology Department of Electrical and Computer Engineering Department of Surgery University of Toronto 1 King s College Circle Toronto ON M5S 1A8 Canada. Samuel Lunenfeld Research Institute Mount Sinai Hospital 600 University Avenue Toronto ON M5G 1X5 Canada. Division of Cell and Molecular Biology Toronto Western Research Institute and Krembil Neuroscience Center 399 Bathurst St. Toronto ON M5T 2S8 Canada. The Hospital for Sick Children 555 University Ave. Toronto ON M5G 1X8 Canada. These authors contributed equally to this work. Correspondence Timothy Hughes. E-mail t.hughes@utoronto.c Published 6 December 2004 Journal of Biology 2004 3 21 The electronic version of this article is the complete one and can be found online at http jbiol.com content 3 5 21 2004 Zhang et al. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Received 1 September 2004 Revised 13 October 2004 Accepted 18 October 2004 Abstract Background Large-scale quantitative analysis of transcriptional co-expression has been used to dissect regulatory networks and to predict the functions of new genes discovered by genome sequencing in model organisms such as yeast. Although the idea that tissue-specific expression is .