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Báo cáo vật lý: "Synthesis of Hydroxyl Radical Scavengers from Benzalacetone and its Derivatives"

Tuyển tập các báo cáo nghiên cứu khoa học trên tạp chí khoa học vật lý quốc tế đề tài: Synthesis of Hydroxyl Radical Scavengers from Benzalacetone and its Derivatives | Journal of Physical Science Vol. 19 2 61-68 2008 61 Synthesis of Hydroxyl Radical Scavengers from Benzalacetone and its Derivatives Sri Handayani and Indyah Sulistyo Arty Department of Chemical Education Faculty of Mathematics and Natural Sciences State University of Yogyakarta Karangmalang Depok Yogyakarta 55283 Indonesia Corresponding author handayani137uny@yahoo.com Abstract Synthesis of hydroxyl radical scavengers from benzalacetone and its derivatives has been done. Benzalacetone synthesis was done by crossed aldol condensation between benzaldehyde and acetone with 1 1 mol ratio while dibenzalacetone in 2 1 mol ratio. Benzalacetone derivatives were synthesized by replacing benzaldehyde with its derivatives i.e. p-anisaldehyde veratraldehyde and cinnamaldehyde. The compounds that were active as radical scavengers based on the IC50 value from the highest level were dib enzalace tone veratralacetone dicinnamalacetone diveratralacetone and anisalacetone. Keywords benzalacetone and its derivatives IC50 hydroxyl radical scavenger 1. INTRODUCTION In recent years epidemiological studies show that consumption of food with high phenolic content correlates with decreasing cardiovascular diseases.1 2 Phenolic compounds may produce their beneficial effect by scavenging free radicals. There has been much researchs which showed the implication of oxidative and free radical in the mediated reaction on the degenerative processes related to aging and other diseases.3 4 Several methods both in vivo and in vitro have been developed to measure antioxidant performance. These methods focus on different mechanisms of antioxidant including scavenging of oxygen and hydroxyl radicals 5 reduction of lipid peroxyl radical inhibition of lipid peroxidation or chelation of metal ions. Thus some methods that are based on the mechanisms include p-carotene bleaching method 6 DPPH assay 7 8 thiobarbituric acid reactive substance TBARS method 9 lipid peroxidation 10 11 and deoxyribose assay.12 .