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Báo cáo y học: "Antiviral therapy of HCV in the cirrhotic and transplant candidate"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Antiviral therapy of HCV in the cirrhotic and transplant candidate. | Int. J. Med. Sci. 2006 3 75 Review International Journal of Medical Sciences ISSN 1449-1907 www.medsci.org 2006 3 2 75-78 2006 Ivyspring International Publisher. All rights reserved Antiviral therapy of HCV in the cirrhotic and transplant candidate Steven K. Herrine and Victor J. Navarro Division of Gastroenterology and Hepatology Thomas Jefferson University 132 S. 10th Street Suite 450 Philadelphia PA 19107 USA. Corresponding address Steven K. Herrine MD Division of Gastroenterology and Hepatology Thomas Jefferson University 132 S. 10th Street Suite 450 Philadelphia PA 19107 USA. Telephone 215.955.5247 Fax 215.503.2146 Email steven.herrine@jefferson.edu Received 2005.12.30 Accepted 2006.03.01 Published 2006.04.01 Despite the improved efficacy of peginterferons the rate of sustained virologic response is suboptimal in cirrhotic patients relative to non-cirrhotic patients. However the treatment of patients With compensated cirrhosis has recently been encouraged by expert panels. Interferon-based therapy may provide additional benefit by reducing the risk of hepatocellular carcinoma in cirrhotic patients as suggested in preliminary studies. Results of two ongoing prospective studies are awaited to answer the important question of the effectiveness of suppressive interferon therapy even in the absence of sustained virologic response. Given the importance of recurrent HCV following liver transplantation attention has been directed toward the antiviral treatment of patients with advanced liver disease. This approach needs to be pursued with caution given the potential morbidity of the therapy. Recently a low accelerating dosage regimen has provided excellent results and is the subject of additional inquiry. Key words hepatitis C virus cirrhosis liver transplantation antiviral therapy 1. Treatment in compensated cirrhosis The response to interferon-based therapy for patients with compensated cirrhosis due to hepatitis C has been evaluated in several trials both as the .