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Báo cáo y học: "Effects of Expanded Human Adipose Tissue-Derived Mesenchymal Stem Cells on the Viability of Cryopreserved Fat Grafts in the Nude Mous"

Tuyển tập các báo cáo nghiên cứu khoa học ngành y học tạp chí Medical Sciences dành cho các bạn sinh viên ngành y tham khảo đề tài: Effects of Expanded Human Adipose Tissue-Derived Mesenchymal Stem Cells on the Viability of Cryopreserved Fat Grafts in the Nude Mouse. | Int. J. Med. Sci. 2011 8 231 International Journal of Medical Sciences 2011 8 3 231-238 Research Paper Effects of Expanded Human Adipose Tissue-Derived Mesenchymal Stem Cells on the Viability of Cryopreserved Fat Grafts in the Nude Mouse Myung-Soon Ko1 2 Ji-Youl Jung2 Il-Seob Shin1 Eun-Wha Choi3 Jae-Hoon Kim2 Sung Keun Kang1 Jeong Chan Ra1 x 1. Stem Cell Research Center RNL BIO Co. Ltd Seoul 153-803 Republic of Korea 2. College of Veterinary Medicine Jeju National University Jeju 690-756 Republic of Korea 3. Laboratory Animal Research Center Samsung Biomedical Research Institute 50 Irwon-dong Gangnam-gu Seoul 135-710 Republic of Korea H Corresponding author Jeong Chan Ra D.V.M. Ph.D. Stem Cell Research Center RNL BIO Co. Ltd Seoul 153-803 Republic of Korea. Tel 82-2-858-8021 Fax 82-2-858-8140 E-mail jcra@rnl.co.kr Ivyspring International Publisher. This is an open-access article distributed under the terms of the Creative Commons License http creativecommons.org licenses by-nc-nd 3.0 . Reproduction is permitted for personal noncommercial use provided that the article is in whole unmodified and properly cited. Received 2011.01.18 Accepted 2011.02.25 Published 2011.03.14 Abstract Adipose-derived mesenchymal stem cells AdMSCs augment the ability to contribute to microvascular remodeling in vivo and to modulate vascular stability in fresh fat grafts. Although cryopreserved adipose tissue is frequently used for soft tissue augmentation the viability of the fat graft is poor. The effects of culture-expanded human adipose tissue-derived mesenchymal stem cells hAdMSCs on the survival and quality of the cryopreserved fat graft were determined. hAdMSCs from the same donor were mixed with fat tissues cryopreserved at -70 C for 8 weeks and injected subcutaneously into 6-week-old BALB c-nu nude mice. Graft volume and weight were measured and histology was evaluated 4 and 15 weeks post-transplantation. The hAdMSC-treated group showed significantly enhanced graft volume and .