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Báo cáo y học: "Current state of cartilage tissue engineering"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Current state of cartilage tissue engineering. | Available online http arthritis-research.eom content 5 5 235 Commentary Current state of cartilage tissue engineering Richard Tuli Wan-Ju Li and Rocky S Tuan Cartilage Biology and Orthopaedics Branch National Institute of Arthritis and Musculoskeletal and Skin Diseases Department of Health and Human Services National Institutes of Health Bethesda Maryland USA Correspondence Rocky S Tuan e-mail Tuanr@mail.nih.gov Received 2 Jun 2003 Revisions requested 16 Jul 2003 Revisions received 30 Jul 2003 Accepted 31 Jul 2003 Published 8 Aug 2003 Arthritis Res Ther 2003 5 235-238 DOI 10.1186 ar991 Abstract Damage to cartilage is of great clinical consequence given the tissue s limited intrinsic potential for healing. Current treatments for cartilage repair are less than satisfactory and rarely restore full function or return the tissue to its native normal state. The rapidly emerging field of tissue engineering holds great promise for the generation of functional cartilage tissue substitutes. The general approach involves a biocompatible structurally and mechanically sound scaffold with an appropriate cell source which is loaded with bioactive molecules that promote cellular differentiation and or maturation. This review highlights aspects of current progress in cartilage tissue engineering. Keywords biomaterials cartilage mesenchymal progenitor cells tissue engineering Introduction Cartilage degeneration caused by congenital abnormalities or disease and trauma is of great clinical consequence given the limited intrinsic healing potential of the tissue. Because of the lack of blood supply and subsequent wound-healing response damage to cartilage alone or chondral lesions results in an incomplete attempt at repair by local chondrocytes. Full-thickness articular cartilage damage or osteochondral lesions allow for the normal inflammatory response but result in inferior fibrocartilage formation. To prevent progressive joint degeneration in diseases such as osteoarthritis surgical