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Báo cáo y học: "Autoantibody profile in systemic lupus erythematosus with psychiatric manifestations: a role for anti-endothelial-cell antibodies"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Autoantibody profile in systemic lupus erythematosus with psychiatric manifestations: a role for anti-endothelial-cell antibodies. | Available online http arthritis-research.eom content 6 4 R366 Research article Autoantibody profile in systemic lupus erythematosus with psychiatric manifestations a role for anti-endothelial-cell antibodies Fabrizio Conti1 Cristiano Alessandri1 Daniela Bompane1 Michele Bombardieri1 Francesca Romana Spinelli1 Anna Carlotta Rusconi2 and Guido Valesini1 1Cattedra di Reumatologia Dipartimento di Clinica e Terapia Medica Applicata - Università degli Studi di Roma La Sapienza Rome Italy 2Dipartimento di Scienze Psichiatriche e Medicina Psicologica Università degli Studi di Roma La Sapienza Rome Italy Corresponding author Guido Valesini guido.valesini@uniroma1.it Received 29 Mar 2004 Revisions requested 16 Apr 2004 Revisions received 7 May 2004 Accepted 18 May 2004 Published 17 Jun 2004 Arthritis Res Ther 2004 6 R366-R372 DOI 10.1186 ar1198 2004 Conti et al. licensee BioMed Central Ltd. This is an Open Access article verbatim copying and redistribution of this article are permitted in all media for any purpose provided this notice is preserved along with the article s original URL. Open Access Abstract This study was performed to determine the correlation between psychiatric manifestations and several autoantibodies that might participate in the pathogenesis of psychiatric disorders in the course of systemic lupus erythematosus SLE . Fifty-one unselected outpatients with SLE were enrolled. Psychiatric evaluation was performed according to the Diagnostic and Statistical Manual of Mental Disorders 4th edition. The prevalence of antibodies against endothelial cells AECA cardiolipin P2 glycoprotein I Ro Ro52 La glial fibrillary acidic protein ribosomal P protein dsDNA and nucleosomes was assessed by experimental and commercial enzyme-linked immunosorbent assays. According to the cutoff value AECA were present in 11 of 17 64.7 SLE patients with psychosis and mood disorders and in 10 of 34 29.4 patients without psychiatric manifestations other than anxiety P 0.03 . Moreover .