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Báo cáo y học: "Expression of CD147 on monocytes/macrophages in rheumatoid arthritis: its potential role in monocyte accumulation and matrix metalloproteinase production"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Expression of CD147 on monocytes/macrophages in rheumatoid arthritis: its potential role in monocyte accumulation and matrix metalloproteinase production. | Available online http arthritis-research.eom content 7 5 R1023 Research article Expression of CD147 on monocytes macrophages in rheumatoid arthritis its potential role in monocyte accumulation and matrix metalloproteinase production Ping Zhu1 Jin Ding1 Jun Zhou2 Wei-Jia Dong1 Chun-Mei Fan1 and Zhi-Nan Chen2 Department of Clinical Immunology Xijing Hospital Fourth Military Medical University Xi an Shaanxi Province China 2Department of Cell Biology Fourth Military Medical University Xi an Shaanxi Province China Corresponding author Zhi-Nan Chen chcerc2@fmmu.edu.cn Received 5 Feb 2005 Revisions requested 15 Mar 2005 Revisions received 9 May 2005 Accepted 31 May 2005 Published 23 Jun 2005 Arthritis Research Therapy 2005 7 R1023-R1033 DOI 10.1186 ar1778 This article is online at http arthritis-research.com content 7 5 R1023 2005 Zhu et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Monocytes macrophages play an important role in rheumatoid arthritis RA pathogenesis. They can activate fibroblasts through many molecules including IL-1 and tumor necrosis factor-alpha but there have been very few reports on the role of CD147 in RA. In our study the results of flow cytometry reveal that the mean fluorescence intensity MFI of CD147 expression on CD14 monocytes of peripheral blood from RA patients was higher than that in normal control and ankylosing spondylitis AS patients. The MFI of CD147 expression on the CD14 monocytes in RA synovial fluid was higher than that in RA peripheral blood. Immunohistochemical staining shows that CD147 expression in RA synovium correlated with matrix metalloproteinase MMP -1 expression. A double immunofluorescent assay shows that CD147 was expressed on CD68 cells in RA synovium.