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Báo cáo y học: " Molecular mechanisms of autoimmunity triggered by microbial infection"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Molecular mechanisms of autoimmunity triggered by microbial infection. | Available online http arthritis-research.eom content 7 5 215 Review Molecular mechanisms of autoimmunity triggered by microbial infection Hans-Joachim Anders Daniel Zecher Rahul D Pawar and Prashant S Patole Medical Policlinic Ludwig-Maximilians-University Munich Germany Corresponding author Hans-Joachim Anders hjanders@med.uni-muenchen.de Published 30 August 2005 This article is online at http arthritis-research.com content 7 5 215 2005 BioMed Central Ltd Arthritis Research Therapy 2005 7 215-224 DOI 10.1186 ar1818 Abstract Autoimmunity can be triggered by microbial infection. In this context the discovery of Toll-like receptors TLRs provides new insights and research perspectives. TLRs induce innate and adaptive antimicrobial immune responses upon exposure to common pathogen-associated molecules including lipopeptides lipopolysaccharides and nucleic acids. They also have the potential however to trigger autoimmune disease as has been revealed by an increasing number of experimental reports. This review summarizes important facts about TLR biology available data on their role in autoimmunity and potential consequences for the management of patients with autoimmune disease. Introduction Autoimmunity is believed to develop from genetic predispositions while the onset of autoimmune tissue injury or disease flare is often triggered by microbial infection. Diseases such as type I diabetes mellitus lupus erythematosus myocarditis rheumatoid arthritis and multiple sclerosis often manifest themselves in association with microbial infection. Patients with chronic forms of autoimmunity may experience symptomatic disease flares following infections. These clinical observations raise a set of questions what classes of receptors recognize microbes or vaccine adjuvants in the host What molecular mechanisms induce immune activation upon recognition of the pathogen And how does antimicrobial immunity modulate tolerance Answers to these questions are expected from the recent .