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Báo cáo y học: "Synovial expression of IL-15 in rheumatoid arthritis is not influenced by blockade of tumour necrosis factor"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Synovial expression of IL-15 in rheumatoid arthritis is not influenced by blockade of tumour necrosis factor. | Available online http arthritis-research.eom content 8 1 R18 Research article Synovial expression of IL-15 in rheumatoid arthritis is not influenced by blockade of tumour necrosis factor Sofia Ernestam1 Erik af Klint2 Anca Irinel Catrina2 Erik Sundberg3 Marianne Engstrom2 Lars Klareskog2 and Ann-Kristin Ulfgren2 Department of Rheumatology Karolinska University Hospital S-141 86 Stockholm Sweden 2Department of Medicine Rheumatology Unit Karolinska Institutet Karolinska University Hospital Stockholm Sweden 3Department of Women and Child Health Pediatric Rheumatology Research Unit Karolinska Institutet Karolinska University Hospital Stockholm Sweden Corresponding author Sofia Ernestam sofia.ernestam@karolinska.se Received 8 Jul 2005 Revisions requested 16 Aug 2005 Revisions received 6 Oct 2005 Accepted 21 Nov 2005 Published 28 Dec 2005 Arthritis Research Therapy 2006 8 R18 doi 10.1186 ar1871 This article is online at http arthritis-research.com content 8 1 R1 8 2005 Ernestam et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Blockade of tumour necrosis factor TNF is an effective treatment in rheumatoid arthritis RA but both non-responders and partial responders are quite frequent. This suggests that other pro-inflammatory cytokines may be of importance in the pathogenesis of RA and as possible targets for therapy. In this study we investigated the effect of TNF blockade infliximab on the synovial expression of IL-15 in RA in relation to different cell types and expression of other cytokines to elucidate whether or not IL-15 is a possible target for therapy independently of TNF blockade. Two arthroscopies with multiple biopsies were performed on nine patients with RA and knee-joint synovitis before and