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Báo cáo y học: "Association of functional variants of PTPN22 and tp53 in psoriatic arthritis: a case-control study"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài:Association of functional variants of PTPN22 and tp53 in psoriatic arthritis: a case-control study. | Available online http arthritis-research.eom content 8 1 R27 Research article Association of functional variants of PTPN22 and tp53 in psoriatic arthritis a case-control study Christopher Butt1 Lynette Peddle1 Celia Greenwood2 Sean Hamilton1 Dafna Gladman3 and Proton Rahman1 1Memorial University of Newfoundland Hospital for Sick Children Department of Public Health Sciences University of Toronto Toronto Canada 2Genetics and Genomic Biology Hospital for Sick Children Department of Public Health Sciences University of Toronto Toronto Canada 3University Health Network Toronto Western Hospital University of Toronto Toronto Canada Corresponding author Proton Rahman prahman@mun.ca Received 25 Jul 2005 Revisions requested 18 Aug 2005 Revisions received 25 Oct 2005 Accepted 7 Dec 2005 Published 3 Jan 2006 Arthritis Research Therapy 2006 8 R27 doi 10.1186 ar1 880 This article is online at http arthritis-research.com content 8 1 R27 2006 Butt et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Recent studies have implicated PTPN22 and tp53 in susceptibility to several autoimmune diseases including rheumatoid arthritis suggesting that these genes are important in maintaining immune homeostasis. Because autoimmune diseases may share similar susceptibility loci investigation of these genes in psoriatic arthritis PsA is of potential relevance. As a result we investigated known coding polymorphisms in PTPN22 and tp53 in a homogenous Caucasian PsA cohort from Newfoundland Canada and an admixed Caucasian PsA cohort from Toronto Canada. We observed a moderate association of the R620W variant of PTPN22 with PsA in the Toronto population only. Because of the conflicting findings reported regarding the association of .