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Báo cáo y học: "Radiographic joint damage in rheumatoid arthritis is associated with differences in cartilage turnover and can be predicted by serum biomarkers: an evaluation from 1 to 4 years after diagnosis"

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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Radiographic joint damage in rheumatoid arthritis is associated with differences in cartilage turnover and can be predicted by serum biomarkers: an evaluation from 1 to 4 years after diagnosis. | Available online http arthritis-research.eom content 8 1 R31 Open Access Research article Radiographic joint damage in rheumatoid arthritis is associated with differences in cartilage turnover and can be predicted by serum biomarkers an evaluation from 1 to 4 years after diagnosis SMM Verstappen1 AR Poole2 M lonescu2 LE King3 M Abrahamowicz4 DM Hofman5 JWJ Bijlsma1 FPJG Lafeber1 and the Utrecht Rheumatoid Arthritis Cohort Study group SRU Department of Rheumatology and Clinical Immunology University Medical Center Utrecht The Netherlands 2Joint Disease Laboratory Shriners Hospital for Children Departments of Surgery and Medicine McGill University Montreal Canada 3IBEX Pharmaceuticals Montreal Canada department of Epidemiology and Biostatistics McGill University Montreal Canada department of Rheumatology Hilversum Hospital Hilversum The Netherlands Corresponding author SMM Verstappen s.verstappen@azu.nl Received 11 Jul 2005 Revisions requested 22 Aug 2005 Revisions received 28 Nov 2005 Accepted 9 Dec 2005 Published 10 Jan 2006 Arthritis Research Therapy 2006 8 R31 doi 10.1186 ar1 882 This article is online at http arthritis-research.com content 8 1 R31 2006 Verstappen et al. licensee BioMed Central Ltd. This is an openaccess article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction The objective of this study was to determine whether serum biomarkers for degradation and synthesis of the extracellular matrix of cartilage are associated with and can predict radiographic damage in patients with rheumatoid arthritis RA . Methods Clinical and radiographic data of 87 RA patients were recorded 1 year after disease onset and then annually up to four years. Serum concentrations of four cartilage biomarkers were determined at these time points a neoepitope formed by .

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