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Báo cáo y học: "Human pregnancy safety for agents used to treat rheumatoid arthritis: adequacy of available information and strategies for developing post-marketing data"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Human pregnancy safety for agents used to treat rheumatoid arthritis: adequacy of available information and strategies for developing post-marketing data. | Available online http arthritis-research.eom content 8 4 215 Review Human pregnancy safety for agents used to treat rheumatoid arthritis adequacy of available information and strategies for developing post-marketing data Christina D Chambers1 2 Zuhre N Tutuneu3 Diana Johnson1 and Kenneth L Jones1 1 Department of Pediatrics University of California San Diego CA USA 2Department of Family and Preventive Medicine University of California San Diego CA USA 3Department of Medicine University of California San Diego CA USA Corresponding author Christina D Chambers chchambers@ucsd.edu Published 14 June 2006 This article is online at http arthritis-research.com content 8 4 215 2006 BioMed Central Ltd Arthritis Research Therapy 2006 8 225 doi 10.1186 ar1977 Abstract For female patients with rheumatoid arthritis the availability of a host of new disease modifying antirheumatic drugs has raised important questions about fetal safety if a woman becomes pregnant while she is being treated. In addition there is limited safety information regarding many of the older medications commonly used to treat rheumatoid arthritis in women of reproductive age. Current summary pregnancy risk information for selected medications used to treat rheumatoid arthritis is reviewed in the context of the pregnancy label category. In addition the strengths and weaknesses of post-marketing strategies for developing new pregnancy safety information are described. Introduction For female patients with rheumatoid arthritis RA the availability of a host of new disease modifying antirheumatic drugs DMARDs has raised important questions about fetal safety if a woman becomes pregnant while she is being treated. In addition there is limited safety information regarding many of the older medications commonly used to treat RA in women of reproductive age. Although pre-marketing clinical trials and post-marketing safety studies can address questions regarding safety in most segments of the population pregnant .