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Báo cáo y học: "Fibroblast activation protein is expressed by rheumatoid myofibroblast-like synoviocytes"

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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Fibroblast activation protein is expressed by rheumatoid myofibroblast-like synoviocytes. | Available online http arthritis-research.eom content 8 6 R1 71 Open Access Research article Fibroblast activation protein is expressed by rheumatoid myofibroblast-like synoviocytes Stefan Bauer1 Michael C Jendro2 Andreas Wadle1 Sascha Kleber1 Frank Stenner1 Robert Dinser3 Anja Reich2 Erica Faccin1 Stefan Godde4 Harald Dinges5 Ulf Muller-Ladner3 and Christoph Renner1 1Oncology Department UniversitatsSpital Zurich Ramistrasse 100 8091 Zurich Switzerland 2Med. Department I Universitat des Saarlandes Kirrbergstrasse 66421 Homburg Saar Germany 3Department of Internal Medicine and Rheumatology University of Giessen and Kerckhoff-Clinic Benekestrasse 2-8 61231 Bad Nauheim Germany 4Orthopedic Department Universitat des Saarlandes Kirrbergstrasse 66421 Homburg Saar Germany 5Orthopedic Clinic Westpfalz-Klinikum Im Flur 1 66869 Kusel Germany Corresponding author Stefan Bauer stefan.bauer@usz.ch Received 31 Mar 2006 Revisions requested 10 May 2006 Revisions received 2 Oct 2006 Accepted 14 Nov 2006 Published 14 Nov 2006 Arthritis Research Therapy 2006 8 R171 doi 10.1186 ar2080 This article is online at http arthritis-research.com content 8 6 R171 2006 Bauer et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Fibroblast activation protein FAP as described so far is a type II cell surface serine protease expressed by fibroblastic cells in areas of active tissue remodelling such as tumour stroma or healing wounds. We investigated the expression of FAP by fibroblast-like synoviocytes FLSs and compared the synovial expression pattern in rheumatoid arthritis RA and osteoarthritis OA patients. Synovial tissue from diseased joints of 20 patients 10 patients with refractory RA and 10 patients with end-stage OA was collected during .

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