Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: MMP-3 expression and release by rheumatoid arthritis fibroblast-like synoviocytes induced with a bacterial ligand of integrin α5β1. | Available online http content 7 1 R118 Research article MMP-3 expression and release by rheumatoid arthritis fibroblast-like synoviocytes induced with a bacterial ligand of integrin a5p1 Mirjam B Zeisel1 Vanessa A Druet1 Dominique Wachsmann1 and Jean Sibilia2 1Inserm 392 Infection et Inflammation Université Louis Pasteur de Strasbourg Faculte de Pharmacie 74 route du Rhin 67400 Illkirch France 2Département de Rhumatologie Hôpitaux Universitaires de Strasbourg Strasbourg France Contributed equally Corresponding author Dominique Wachsmann wachs@ Received 26 Jun 2004 Revisions requested 18 Aug 2004 Revisions received 1 7 Sep 2004 Accepted 12 Oct 2004 Published 24 Nov 2004 Arthritis Res Ther 2005 7 R118-R126 DOI ar1462 2004 Zeisel et al. licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http licenses by which permits unrestricted use distribution and reproduction in any medium provided the original work is cited. Open Access Abstract Fibroblast-like synoviocytes FLSs play a major role in the pathogenesis of rheumatoid arthritis RA by secreting effector molecules that promote inflammation and joint destruction. How these cells become and remain activated is still elusive. Both genetic and environmental factors probably play a role in transforming FLSs into inflammatory matrix-degrading cells. As bacterial products have been detected in the joint and shown to trigger joint inflammation this study was undertaken to investigate whether a bacterial ligand of integrin a5p1 protein I II could contribute to the aggressive behavior of RA FLSs. Protein I II is a pathogen-associated molecular pattern PAMP isolated from oral streptococci that have been identified in the joints of RA patients. The response of RA and osteoarthritis FLSs to protein I II was analyzed using human cancer cDNA expression arrays. RT-PCR and pro-MMP-3 .
