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Báo cáo khoa học: "Radiation recall pneumonitis induced by chemotherapy after thoracic radiotherapy for lung cancer"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học Radiation Oncology cung cấp cho các bạn kiến thức về ngành y đề tài: Radiation recall pneumonitis induced by chemotherapy after thoracic radiotherapy for lung cancer. | Ding et al. Radiation Oncology 2011 6 24 http www.ro-journal.eom content 6 1 24 RADIATION ONCOLOGY RESEARCH Open Access Radiation recall pneumonitis induced by chemotherapy after thoracic radiotherapy for lung cancer - r 1 t 1.31 2w 71 2 1 Xiao Ding Wei Ji Junling Li Xiangru Zhang Luhua Wang Abstract Background Radiation recall pneumonitis RRP describes a rare reaction in previously irradiated area of pulmonary tissue after application of triggering agents. RRP remains loosely characterized and poorly understood since it has so far only been depicted in 8 cases in the literature. The objective of the study is to disclose the general characteristics of RRP induced by chemotherapy after thoracic irradiation for lung cancer and to draw attention to the potential toxicity even after a long time interval from the previous irradiation. Methods Medical records were reviewed. RRP induced by chemotherapy was diagnosed by the history of chemotherapy after radiotherapy clinical presentation and radiographic abnormalities including ground-glass opacity attenuation or consolidation changes within the radiation field plus that radiographic examination of the thorax before showed no radiation pneumonitis. RRP was graded according to Common Terminology Criteria for Adverse Events version 3.0. The characteristics of the 12 RRP cases were analyzed. Results Twelve patients were diagnosed of RRP of who 8 received taxanes. The median time interval between end of radiotherapy and RRP between end of radiotherapy and beginning of chemotherapy and between beginning of chemotherapy and RRP was 95 days 42 days and 47 days respectively. Marked symptomatic and radiographic improvement was observed in the 12 patients after withdrawal of chemotherapy and application of systemic corticosteroids. Seven patients were rechallenged with chemotherapy of whom four with the same kind of agents and showed no recurrence with steroid cover. Conclusions Doctors should pay attention to RRP even after a long