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Báo cáo y học: " Cell therapy for autoimmune diseases"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Cell therapy for autoimmune diseases. | Available online http arthritis-research.eom content 9 2 206 Review Cell therapy for autoimmune diseases Francesco Dazzi1 Jacob M van Laar2 Andrew Cope1 and Alan Tyndall3 1Stem Cell Biology Section Kennedy Institute of Rheumatology Imperial College Faculty of Medicine London UK 2Department of Rheumatology Leiden University Medical Center Leiden The Netherlands 3Department of Rheumatology University of Basel Felix Plattel Spital Basel Switzerland Corresponding author Francesco Dazzi f.dazzi@imperial.ac.uk Published 14 March 2007 This article is online at http arthritis-research.com content 9 2 206 2007 BioMed Central Ltd Arthritis Research Therapy 2007 9 206 doi 10.1186 ar2128 Abstract Cell therapy pioneered for the treatment of malignancies in the form of bone marrow transplantation has subsequently been tested and successfully employed in autoimmune diseases. Autologous haemopoietic stem cell transplantation HSCT has become a curative option for conditions with very poor prognosis such as severe forms of scleroderma multiple sclerosis and lupus in which targeted therapies have little or no effect. The refinement of the conditioning regimens has virtually eliminated transplant-related mortality thus making HSCT a relatively safe choice. Although HSCT remains a nonspecific approach the knowledge gained in this field has led to the identification of new avenues. In fact it has become evident that the therapeutic efficacy of HSCT cannot merely be the consequence of a high-dose immunosuppression but rather the result of a resetting of the abnormal immune regulation underlying autoimmune conditions. The identification of professional and nonprofessional immunosuppressive cells and their biological properties is generating a huge interest for their clinical exploitation. Regulatory T cells found abnormal in several autoimmune diseases have been proposed as central to achieve long-term remissions. Mesenchymal stem cells of bone marrow origin have more recently been shown