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Báo cáo y học: "Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis. | Available online http arthritis-research.eom content 10 4 R94 Open Access Research article Circulating immune complexes contain citrullinated fibrinogen in rheumatoid arthritis Xiaoyan Zhao1 2 Nwora Lance Okeke1 2 Orr Sharpe1 2 Franak M Batliwalla3 Annette T Lee3 Peggy P Ho4 Beren H Tomooka1 2 Peter K Gregersen3 and William H Robinson1 2 1GRECC VA Palo Alto Health Care System 3801 Miranda Avenue Palo Alto CA 94304 USA 2Department of Medicine Division of Immunology and Rheumatology Stanford University School of Medicine 269 Campus Drive West Stanford CA 94305 USA 3Robert S. Boas Center for Genomics and Human Genetics Feinstein Institute for Medical Research 350 Community Drive Manhasset NY 11030 USA 4Department of Neurology and Neurological Sciences Stanford University School of Medicine 269 Campus Drive West Stanford CA 94305 USA Corresponding author William H Robinson wrobins@stanford.edu Received 10 Jun 2008 Revisions requested 1 Jul 2008 Revisions received 22 Jul 2008 Accepted 18 Aug 2008 Published 18 Aug 2008 Arthritis Research Therapy 2008 10 R94 doi 10.1186 ar2478 This article is online at http arthritis-research.com content 10 4 R94 2008 Zhao et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction There is increasing evidence that autoantibodies and immune complexes ICs contribute to synovitis in rheumatoid arthritis RA yet the autoantigens incorporated in ICs in RA remain incompletely characterised. Methods We used the C1q protein to capture ICs from plasma derived from human RA and control patients. Antibodies specific for immunoglobulin were used to detect ICs and fibrinogen antibodies were used to detect fibrinogen-containing ICs. RA and control plasma were separated by liquid chromatography