Đang chuẩn bị liên kết để tải về tài liệu:
Báo cáo y học: "Mesenchymal stem cells in arthritic disease"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Mesenchymal stem cells in arthritic disease. | Available online http arthritis-research.eom content 10 5 223 Review Mesenchymal stem cells in arthritic diseases Faye H Chen and Rocky S Tuan Cartilage Biology and Orthopaedics Branch National Institute of Arthritis and Musculoskeletal and Skin Diseases National Institutes of Health Department of Health and Human Services Building 50 50 South Dr. Bethesda MD 20892 USA Corresponding author Rocky S Tuan tuanr@mail.nih.gov Published 10 October 2008 This article is online at http arthritis-research.com content 10 5 223 2008 BioMed Central Ltd Arthritis Research Therapy 2008 10 223 doi 10.1186 ar2514 Abstract Mesenchymal stem cells MSCs the nonhematopoietic progenitor cells found in various adult tissues are characterized by their ease of isolation and their rapid growth in vitro while maintaining their differentiation potential allowing for extensive culture expansion to obtain large quantities suitable for therapeutic use. These properties make MSCs an ideal candidate cell type as building blocks for tissue engineering efforts to regenerate replacement tissues and repair damaged structures as encountered in various arthritic conditions. Osteoarthritis OA is the most common arthritic condition and like rheumatoid arthritis RA presents an inflammatory environment with immunological involvement and this has been an enduring obstacle that can potentially limit the use of cartilage tissue engineering. Recent advances in our understanding of the functions of MSCs have shown that MSCs also possess potent immunosuppression and anti-inflammation effects. In addition through secretion of various soluble factors MSCs can influence the local tissue environment and exert protective effects with an end result of effectively stimulating regeneration in situ. This function of MSCs can be exploited for their therapeutic application in degenerative joint diseases such as RA and OA. This review surveys the advances made in the past decade which have led to our current understanding of