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Báo cáo y học: " Effects of cyclophosphamide on pulmonary function in patients with scleroderma and interstitial lung disease: a systematic review and meta-analysis of randomized controlled trials and observational prospective cohort studies"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Effects of cyclophosphamide on pulmonary function in patients with scleroderma and interstitial lung disease: a systematic review and meta-analysis of randomized controlled trials and observational prospective cohort studies. | Available online http arthritis-research.eom content 10 5 R124 Research article Effects of cyclophosphamide on pulmonary function in patients with scleroderma and interstitial lung disease a systematic review and meta-analysis of randomized controlled trials and observational prospective cohort studies Carlotta Nannini1 Colin P West2 3 Patricia J Erwin4 and Eric L Matteson1 Open Access Division of Rheumatology Mayo Clinic College of Medicine 200 First Street SW Rochester MN 55905 USA 2Division of General Internal Medicine Mayo Clinic College of Medicine 200 First Street SW Rochester MN 55905 USA 3Division of Biostatistics Mayo Clinic College of Medicine 200 First Street SW Rochester MN 55905 USA 4Medical Library Mayo Clinic College of Medicine 200 First Street SW Rochester MN 55905 USA Corresponding author Carlotta Nannini nannini.carlotta@mayo.edu Received 29 Jun 2008 Revisions requested 29 Jul 2008 Revisions received 2 Oct 2008 Accepted 20 Oct 2008 Published 20 Oct 2008 Arthritis Research Therapy 2008 10 R124 doi 10.11 86 ar2534 This article is online at http arthritis-research.com content 10 5 R1 24 2008 Nannini et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction The purpose of the present study was to systematically review the effect of cyclophosphamide treatment on pulmonary function in patients with systemic sclerosis and interstitial lung disease. Methods The primary outcomes were the mean change in forced vital capacity and in diffusing capacity for carbon monoxide after 12 months of therapy in patients treated with cyclophosphamide. Results Three randomized clinical trials and six prospective observational studies were included for analysis. In the pooled analysis the forced vital capacity