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Báo cáo y học: "Apoptotic cell-mediated suppression of streptococcal cell wall-induced arthritis is associated with alteration of macrophage function and local regulatory T-cell increase: a potential cell-based therapy"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Apoptotic cell-mediated suppression of streptococcal cell wall-induced arthritis is associated with alteration of macrophage function and local regulatory T-cell increase: a potential cell-based therapy? | Available online http arthritis-research.eom content 11 4 R104 Research article Apoptotic cell-mediated suppression of streptococcal cell wall-induced arthritis is associated with alteration of macrophage function and local regulatory T-cell increase a potential cell-based therapy Sylvain Perruche1 2 Philippe Saas2 and Wanjun Chen1 Open Access 1Mucosal Immunology Unit Oral Infection and Immunity Branch National Institute of Dental and Craniofacial Research National Institutes of Health Convent Drive Bethesda MD 20892 USA 2Inserm UMR645 EFS B FC Université of Franche-Comté IFR133 1 Bd A. Fleming 25020 Besancon France Corresponding author Wanjun Chen wchen@dir.nidcr.nih.gov Received 6 Nov 2008 Revisions requested 3 Dec 2008 Revisions received 28 Apr 2009 Accepted 2 Jul 2009 Published 2 Jul 2009 Arthritis Research Therapy 2009 11 R104 doi 10.11 86 ar2750 This article is online at http arthritis-research.com content 11 4 R104 2009 Perruche et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Introduction Experimental streptococcal cell wall SCW -induced arthritis is characterized by two successive phases of the disease. The acute phase occurs early and is associated with an inflammatory process and neutrophil infiltration into the synovium. The second chronic phase is related to effector T-cell activation and the dysregulation of macrophage function. Creation of an immunomodulatory environment has been attributed to apoptotic cells themselves apoptotic cell uptake by phagocytes as well as a less sensibility of phagocytes capturing apoptotic bodies to activation. Therefore we evaluated the potential of apoptotic cell injection to influence the course of inflammation in SCW-induced arthritis in rats. Methods Rat .