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Báo cáo y học: "Connective tissue growth factor promotes articular damage by increased osteoclastogenesis in patients with rheumatoid arthritis"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học General Psychiatry cung cấp cho các bạn kiến thức về ngành y đề tài: Connective tissue growth factor promotes articular damage by increased osteoclastogenesis in patients with rheumatoid arthritis. | Available online http arthritis-research.eom content 11 6 R174 Research article Connective tissue growth factor promotes articular damage by increased osteoclastogenesis in patients with rheumatoid arthritis Kazuhisa Nozawa1 2 Maki Fujishiro1 Mikiko Kawasaki1 Hiroshi Kaneko2 Kazuhisa Iwabuchi1 Mitsuaki Yanagida1 Fujihiko Suzuki3 Keiji Miyazawa4 Yoshinari Takasaki5 Hideoki Ogawa1 Kenji Takamori1 and Iwao Sekigawa1 2 institute for Environment and Gender Specific Medicine Juntendo University Graduate School of Medicine Chiba 2-1-1 Tomioka Urayasu Chiba 279-0021 Japan 2Department of Internal Medicine and Rheumatology Juntendo University Urayasu Hospital 2-1-1 Tomioka Urayasu Chiba 279-0021 Japan 3Department of Pathology Juntendo University Urayasu Hospital 2-1-1 Tomioka Urayasu Chiba 279-0021 Japan 4Central Research Laboratories Kissei Pharmaceutical Co Ltd 4365-1 Hotakakashiwabara Azumino Nagano 399-8304 Japan 5Department of Rheumatology School of Medicine Juntendo University 2-1-1 Hongo Bunkyo Tokyo 113-8421 Japan Corresponding author Kazuhisa Nozawa kazunozawa@aol.com Received 28 Mar 2009 Revisions requested 27 Apr 2009 Revisions received 4 Nov 2009 Accepted 18 Nov 2009 Published 18 Nov 2009 Arthritis Research Therapy 2009 11 R174 doi 10.11 86 ar2863 This article is online at http arthritis-research.com content 11 6 R174 2009 Nozawa et al. licensee BioMed Central Ltd. This is an open access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Open Access Abstract Introduction A protein analysis using a mass spectrometry indicated that there are serum proteins showing significant quantitative changes after the administration of infliximab. Among them connective tissue growth factor CTGF seems to be related to the pathogenesis of rheumatoid arthritis RA . Therefore this study was .