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Báo cáo y học: " Mechanical compression attenuates normal human bronchial epithelial wound healing"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Mechanical compression attenuates normal human bronchial epithelial wound healing. | Respiratory Research BioMed Central Research Mechanical compression attenuates normal human bronchial epithelial wound healing Stephen P Arold1 Nikita Malavia2 and Steven C George 1 2 Open Access Address Department of Biomedical Engineering University of California Irvine USA and 2Department of Chemical Engineering and Materials Science University of California Irvine USA Email Stephen P Arold - scgeorge@uci.edu Nikita Malavia - scgeorge@uci.edu Steven C George - scgeorge@uci.edu Corresponding author Published 12 February 2009 Received 27 October 2008 Respiratory Research 2009 10 9 doi l0.ll86 l465-992l-l0-9 Accepted 12 February 2009 This article is available from http www.biomedcentral.cOm l465-992l l0 9 2009 Arold et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background Airway narrowing associated with chronic asthma results in the transmission of injurious compressive forces to the bronchial epithelium and promotes the release of pro-inflammatory mediators and the denudation of the bronchial epithelium. While the individual effects of compression or denudation are well characterized there is no data to elucidate how these cells respond to the application of mechanical compression in the presence of a compromised epithelial layer. Methods Accordingly differentiated normal human bronchial epithelial cells were exposed to one of four conditions l unperturbed control cells 2 single scrape wound only 3 static compression 6 hours of 30 cmH2O and 4 6 hours of static compression after a scrape wound. Following treatment wound closure rate was recorded media was assayed for mediator content and the cytoskeletal network was .