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Báo cáo y học: " Altered effector function of peripheral cytotoxic cells in COPD"

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Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" Altered effector function of peripheral cytotoxic cells in COPD. | Respiratory Research BioMed Central Research Altered effector function of peripheral cytotoxic cells in COPD Richard A Urbanowicz1 Jonathan R Lamb2 Ian Todd1 Jonathan M Corne3 and Lucy C Fairclough 1 Open Access Address 1COPD Research Group Institute of Infection Immunity and Inflammation The University of Nottingham NG7 2UH UK 2Immunology and Infection Section Division of Cell and Molecular Biology Faculty of Natural Sciences Imperial College London South Kensington London SW7 9AZ UK and 3Department of Respiratory Medicine Nottingham University Hospitals NG7 2UH UK Email Richard A Urbanowicz - rich.urbanowicz@nottingham.ac.uk Jonathan R Lamb - jonathan.lamb@imperial.ac.uk Ian Todd - ian.todd@nottingham.ac.uk Jonathan M Corne - jonathan.corne@nuh.nhs.uk Lucy C Fairclough - lucy.fairclough@nottingham.ac.uk Corresponding author Published 22 June 2009 Received 10 December 2008 Respiratory Research 2009 10 53 doi l0.ll86 l465-992l-l0-53 Accepted 22 June 2009 This article is available from http respiratory-research.cOm content l0 l 53 2009 Urbanowicz et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract_ Background There is mounting evidence that perforin and granzymes are important mediators in the lung destruction seen in COPD. We investigated the characteristics of the three main perforin and granzyme containing peripheral cells namely CD8 T lymphocytes natural killer NK Cd56 CD3- cells and NKT-like CD56 CD3 cells. Methods Peripheral blood mononuclear cells PBMCs were isolated and cell numbers and intracellular granzyme B and perforin were analysed by flow cytometry. Immunomagnetically selected CD8 T lymphocytes NK CD56 CD3- and NKT-like

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