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Báo cáo y học: " Protection from pulmonary ischemia-reperfusion injury by adenosine A2A receptor activation"

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:" " Protection from pulmonary ischemia-reperfusion injury by adenosine A2A receptor activation. | Respiratory Research BioMed Central Open Access Protection from pulmonary ischemia-reperfusion injury by adenosine A2A receptor activation Ashish K Sharma1 Joel Linden2 Irving L Kron1 and Victor E Laubach 1 Address Department of Surgery University of Virginia Health System Charlottesville Virginia USA and 2Department of Medicine University of Virginia Health System Charlottesville Virginia USA Email Ashish K Sharma - aks2n@virginia.edu Joel Linden - jl4v@virginia.edu Irving L Kron - ilk@virginia.edu Victor E Laubach - laubach@virginia.edu Corresponding author Published 26 June 2009 Received 14 April 2009 Respiratory Research 2009 10 58 doi 10.1186 1465-9921-10-58 Accepted 26 June 2009 This article is available from http respiratory-research.cOm content 10 1 58 2009 Sharma et al licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License http creativecommons.org licenses by 2.0 which permits unrestricted use distribution and reproduction in any medium provided the original work is properly cited. Abstract Background Lung ischemia-reperfusion IR injury leads to significant morbidity and mortality which remains a major obstacle after lung transplantation. However the role of various subset s of lung cell populations in the pathogenesis of lung IR injury and the mechanisms of cellular protection remain to be elucidated. In the present study we investigated the effects of adenosine A2A receptor A2AAR activation on resident lung cells after IR injury using an isolated buffer-perfused murine lung model. Methods To assess the protective effects of A2AAR activation three groups of C57BL 6J mice were studied a sham group perfused for 2 hr with no ischemia an IR group 1 hr ischemia 1 hr reperfusion and an IR ATL313 group where ATL313 a specific A2AAR agonist was included in the reperfusion buffer after ischemia. Lung injury parameters and pulmonary function studies were also performed after IR injury in .