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Báo cáo y học: "Increase in markers of airway inflammation after ozone exposure can be observed also in stable treated "

Tuyển tập các báo cáo nghiên cứu về y học được đăng trên tạp chí y học 'Respiratory Research cung cấp cho các bạn kiến thức về ngành y đề tài:Increase in markers of airway inflammation after ozone exposure can be observed also in stable treated . | Vagaggini et al. Respiratory Research 2010 11 5 http respiratory-research.eom content 11 1 5 RESPIRATORY RESEARCH RESEARCH Open Access Increase in markers of airway inflammation after ozone exposure can be observed also in stable treated asthmatics with minimal functional response to ozone Barbara Vagaggini Maria Laura E Bartoli Silvana Cianchetti Francesco Costa Elena Bacci Federico L Dente Antonella Di Franco Laura Malagrinò Pierluigi Paggiaro Abstract Background The discrepancy between functional and inflammatory airway response to ozone has been reported in normal subjects but few data are available for stable asthmatics regularly treated with inhaled corticosteroids. Methods Twenty-three well controlled regularly treated mild-to-moderate asthmatic patients underwent two sequential randomised exposures to either filtered air or ozone 0.3 ppm for 2 hours in a challenge chamber. Pulmonary function PF was monitored and patients with FEV1 decrease greater than 10 from pre-challenge value were considered as responders. Immediately after each exposure exhaled breath condensate EBC was collected to measure malondialdehyde MDA . Six hours after each exposure PF and EBC collection were repeated and sputum was induced to measure inflammatory cell counts and soluble mediators IL-8 and neutrophil elastase . The response to ozone was also evaluated according to the presence of polymorphism in oxidative stress related NQO1 and GSTM1 genes. Results After ozone exposure sputum neutrophils significantly increased in responders n 8 but not in nonresponders n 15 . Other markers of neutrophil activation in sputum supernatant and MDA in EBC significantly increased in all patients but only in nonresponders the increase was significant. In nonresponders sputum eosinophils also significantly increased after ozone. There was a positive correlation between ozone-induced FEV1 fall and increase in sputum neutrophils. No difference in functional or inflammatory response to ozone was .